Synthesis of xanthones: An overview

• Type: Another Publication in an International Scientific Journal
• Date: 2005

Authors

Sousa, ME (Author) FFUP; Pinto, MMM (Author) FFUP

Journal

Title: Current Medicinal Chemistry

Vol. 12

Pages: 2447-2479

ISSN: 0929-8673

Publisher: Bentham Science

Indexing

ISI Proceedings

ISI Web of Knowledge - 121 Citations

Scopus - 120 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-5GH

DOI: 10.2174/092986705774370736

Abstract (EN): Among the known synthetic routes to obtain xanthones, the Grover, Shah, and Shah reaction, the cyclodehydration of 2, 2'-dihydroxybenzophenones and electrophilic cycloacylation of 2-aryloxybenzoic acids are the most popular methods. Due to important biological applications of xanthones, some synthetic strategies leading to more complex derivatives have been widely explored in the past years. Thus, the purpose of this review is to report some recent improvements of the classical synthetic methods as well as of some nonclassical methods to obtain simple oxygenated xanthones. The strategies for introduction of substituents into the xanthonic nucleus are also summarized. Furthermore, different approaches used to synthesize complex structures, with an emphasis on the total synthesis of bioactive natural products, accomplished in the last twenty years, are also discussed. Besides the synthesis of xanthones, the redetivity of the xanthonic nucleus and its role as a key intermediate for the synthesis of other important classes of compounds are also highlighted.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 33