Synthesis and antimalarial properties of new chloro-9H-xanthones with an aminoalkyl side chain

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Cesar Portela (Author) Other; Carlos M M Afonso (Author) FFUP; Madalena M M Pinto (Author) FFUP; Dinora Lopes (Author) Other; Fatima Nogueira (Author) Other; Virgilio do Rosario (Author) Other

Journal

Title: Chemistry and Biodiversity

Vol. 4 No. 7

Pages: 1508-1519

ISSN: 1612-1872

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 21 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-CQ3

DOI: 10.1002/cbdv.200790130

Abstract (EN): The synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones, carrying a [2(di ethylamino)ethyl] amino group in position 1, are reported. All compounds were found to be active towards the chloroquine-susceptible and chloroquine-resistant strains 3D7 and Dd2, resp., of the protozoa parasite Plasmodium falciparum. Especially one compound, 6-chloro-1-{[2-(diethylamino)-ethyl]ami no}-9H-xanthen-9-one (1k), was found to exhibit significant in vitro activity (IC50=3.9 mu M) towards the resistant Dd2 strain.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12