Constituents of Polyalthia jucunda and their cytotoxic effect on human cancer cell lines

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Areerat Suedee (Author) Other; Ing On Mondranondra (Author) Other; Anake Kijjoa (Author) ICBAS; Madalena Pinto (Author) FFUP; Nair Nazareth (Author) Other; Maria S Sao Jose Nascimento (Author) FFUP; Artur M S Silva (Author) Other; Werner Herz (Author) Other

Journal

Title: Pharmaceutical Biology

Vol. 45

Pages: 575-579

ISSN: 1388-0209

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 4 Citations

Scientific classification

FOS: Engineering and technology > Medical engineering

Other information

Authenticus ID: P-004-E5Y

DOI: 10.1080/13880200701501300

Abstract (EN): 4- Hydroxy- 4,7- dimethyl- alpha- tetralone ( 1), 4,5- dihydroblumenol A ( 2), N- trans- feruloyltyramine ( 3), and 24 - methylenelanosta-7, 9( 11)- dien- 3- beta, 15 alpha- diol ( 4) were isolated from the stem bark of Polyalthia jucunda ( Piere) Finet & Gagnep ( Annonaceae). All the compounds were evaluated for their effects on growth of four human tumor cell lines [ ER(+) MCF- 7, ER( -) MDA- MB- 23, SF 268, and NCI- H460] and of a non - tumor cell line ( MRC- 5). Only compound 4 exhibited a dose- dependent growth inhibitory effect against both tumor and non - tumor cell lines but with less effect on the latter. Using the TUNEL assay, it was found that the inhibitory effect of compound 4 on NCI- H460 cells was probably caused by apoptosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5