Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients

• Type: Article in International Scientific Journal
• Date: 2009

Authors

nunes, cs (Author) Other; ferreira, da (Author) Other; antunes, l (Author) FCUP; lobo, f (Author) Other; santos, ia (Author) Other; amorim, p (Author) Other

Journal

Title: Journal of Clinical Anesthesia

Vol. 21

Pages: 3-8

ISSN: 0952-8180

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-003-NGW

DOI: 10.1016/j.jclinane.2008.06.011

Abstract (EN): Study Objective: To investigate whether a patient's propofol effect-site concentration at return 10 Consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design: Prospective study. Setting: Operating room. Patients: 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score > 15, and scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of propofol and remifentanil. Interventions: A constant propofol infusion was administered until LOC. At LOC, remifentanil started with a plasma concentration target of 2.5 ng mL(-1). Main Results: Propofol concentration at LOC was 4.9 +/- 1 mu g mL(-1). At ROC, propofol and remifentanil concentrations were 1.16 +/- 0.3 mu g mL(-1) and 3.41 +/- 1.5 mu g mL(-1). Significant correlation was observed between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient age (48.7 +/- 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age. Conclusions: The correlation between propofol concentrations at ROC and LOC was improved by inclusion of patient age data.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6