Nanoparticles in Molecular Diagnostics

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

Pedro V Baptista (Author) Other; Goncalo Doria (Author) Other; Pedro Quaresma (Author) Other; Miguel Cavadas (Author) Other; Cristina S Neves (Author) Other; Ines Gomes (Author) Other; Peter Eaton (Author) Other; Eulalia Pereira (Author) FCUP; Ricardo Franco (Author) Other

Journal

Title: Progress in Molecular Biology and Translational Science

Vol. 13

Pages: 427-488

ISSN: 1877-1173

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 35 Citations

Scopus - 48 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-002-WYT

DOI: 10.1016/b978-0-12-416020-0.00011-5

Abstract (EN): The aim of this chapter is to provide an overview of the available and emerging molecular diagnostic methods that take advantage of the unique nanoscale properties of nanoparticles (NPs) to increase the sensitivity, detection capabilities, ease of operation, and portability of the biodetection assemblies. The focus will be on noble metal NPs, especially gold NPs, fluorescent NPs, especially quantum dots, and magnetic NPs, the three main players in the development of probes for biological sensing. The chapter is divided into four sections: a first section covering the unique physicochemical properties of NPs of relevance for their utilization in molecular diagnostics; the second section dedicated to applications of NPs in molecular diagnostics by nucleic acid detection; and the third section with major applications of NPs in the area of immunoassays. Finally, a concluding section highlights the most promising advances in the area and presents future perspectives.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 62