Dipyrone and aminopyrine are effective scavengers of reactive nitrogen species

• Type: Article in International Scientific Journal
• Date: 2006

Authors

David Costa (Author) Other; Abel Vieira (Author) Other; Eduarda Fernandes (Author) FFUP

Journal

Title: Redox Report

Vol. 11 No. 3

Pages: 136-142

ISSN: 1351-0002

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 29 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-004-KMA

DOI: 10.1179/135100006x116637

Abstract (EN): Reactive nitrogen species (RNS), namely nitric oxide (NO center dot) and peroxynitrite (ONOO-) are produced in the inflammatory sites and may contribute to the deleterious effects of inflammation. The aim of the present study was to evaluate the putative scavenging effect of a particular group of non-steroidal anti-inflammatory drugs (NSAIDs), the pyrazolone derivatives dipyrone, aminopyrine, isopropylantipyrine, and antipyrine against RNS, using in vitro non-cellular screening systems. The results obtained showed that dipyrone and aminopyrine were highly potent scavengers of NO center dot and ONOO- while antipyrine exerted little effect and isopropylantipyrine no effect whatsoever against these two RNS and that, in the presence of bicarbonate, the scavenging potencies of both dipyrone and aminopyrine were slightly decreased. It could thus be inferred that the observed scavenging effects may be of therapeutic benefit for patients under anti-inflammatory treatment with dipyrone and aminopyrine in the case of overproduction of RNS. On the other hand, the possible depletion of physiological NO center dot concentrations, namely at the gastrointestinal tract as well as the formation of reactive derivatives of aminopyrine and/or dipyrone, resulting from their reaction with RNS, may otherwise be harmful for these patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7