Antioxidant activity of beta-blockers: An effect mediated by scavenging reactive oxygen and nitrogen species?

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Ana Gomes (Author) Other; David Costa (Author) Other; Jose L F C Lima (Author) FFUP; Eduarda Fernandes (Author) FFUP

Journal

Title: Bioorganic and Medicinal Chemistry

Vol. 14

Pages: 4568-4577

ISSN: 0968-0896

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 70 Citations

Scopus - 78 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-JQP

DOI: 10.1016/j.bmc.2006.02.023

Abstract (EN): The therapeutic effects of beta-blockers are normally explained by their capacity to block the beta-adrenoceptors, however, some of the beneficial cardiovascular effects shown by this group of compounds have already been associated with the antioxidant properties that some of them seem to possess. The beta-blockers atenolol, labetalol, metoprolol, pindolol, propranolol, sotalol, timolol, and carvedilol were tested for their putative scavenging activity for ROS (O-2(center dot-), H2O2, HO center dot, HOCl, and ROO center dot) and RNS ((NO)-N-center dot and ONOO-). Some of the studied compounds are effective ROS and/or RNS scavengers, these effects being possibly useful in preventing oxidative damage verified in hypertension as well as in other cardiovascular diseases that frequently emerge in association with oxidative stress.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10