Saturated fatty acids intake in relation to C-reactive protein, adiponectin, and leptin: A population-based study

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Susana Santos (Author) Other; Andreia Oliveira (Author) FMUP; Susana Casal (Author) FFUP; Carla Lopes (Author) FMUP

Journal

Title: Nutrition

Vol. 29

Pages: 892-897

ISSN: 0899-9007

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 22 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-005-06X

DOI: 10.1016/j.nut.2013.01.009

Abstract (EN): Objective: Evidence on the relation of saturated fatty acids (SFA) with inflammatory markers and adipokines is scarce and inconsistent. This study aimed to evaluate the association of the intake of total SFA, their subtypes (lauric, myristic, palmitic, and stearic acids), and SFA to polyunsaturated fatty acids (PUFA) ratio (SFA/PUFA ratio) with serum concentrations of high-sensitivity C-reactive protein (hs-CRP), adiponectin, and leptin among Portuguese adults. Methods: We studied 395 non-institutionalized inhabitants of Porto (52.2% women; age range: 26-64 y) who were evaluated in 2010-2011, as part of EPIPorto study. Fatty acids intake was assessed with a validated semi-quantitative food frequency questionnaire. Blood was sampled after an overnight fast and serum concentrations of hs-CRP (through particle-enhanced immunonephelometry), adiponectin, and leptin (through radioimmunoassay) were determined. Regression coefficients (beta) and 95% confidence intervals (CI) were obtained from linear regression models, stratified by sex. Results: After adjusting for age, education, regular physical exercise, smoking, and central body fat percentage, hs-CRP was significantly and positively associated with lauric (beta = 0.218; 95% CI, 0.071-0.365) and myristic acids (beta = 0.220; 95% CI, 0.073-0.368) and with SFA/PUFA ratio (beta = 0.171; 95% CI, 0.022-0.320) in men, but not in women. For adiponectin and leptin, no significant associations with SFA intake were observed in either sex. Conclusions: A detrimental role of lauric and myristic acids and of high SFA/PUFA ratio is suggested by their association with elevated hs-CRP concentrations in men. Our findings may be helpful in the planning of dietary modifications aimed at the modulation of inflammatory activity that could be an intermediate step to coronary events.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6