Chromone: A valid scaffold in medicinal chemistry

• Type: Article in International Scientific Journal
• Date: 2014

Authors

gaspar, am (Author) Other; matos, mj (Author) Other; garrido, jmpj (Author) Other; uriarte, e (Author) Other; borges, ffm (Author) FCUP

Journal

Title: Chemical Reviews

Vol. 114

Pages: 4960-4992

ISSN: 0009-2665

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 577 Citations

Scopus - 587 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Physical sciences > Chemistry > Applied chemistry > Pharmaceutical chemistry

Other information

Authenticus ID: P-009-CX4

DOI: 10.1021/cr400265z

Abstract (EN): Simple chromones, a group of heterocyclic compounds, have been studied as a fruitful approach in medicinal chemistry and consequently, with value as a privileged scaffold. The main classic routes for the obtention of simple chromones from ortho-hydroxyarylalkylketones enclose three synthetic approaches, synthesis via Claisen condensation (classic Claisen condensation, Baker-Venkatamaran, and Kostanecki-Robinson reaction), synthesis via benzopyrylium salts and via Vilsmeier-Haack reaction. Chromones can be obtained by the reaction of a phenol with acetylenic dicarboxylic acids or esters or with chlorofumaric acid, or other analogues, in basic conditions, such as metallic sodium. Heterocyclic-substituted chromones are probably one of the most representative derivatives as these types of entities are very important as ligands in the medicinal chemistry artwork. It is expected that the research performed with type of compounds will uncover further interesting aspects in the medicinal field.

Language: English

Type (Professor's evaluation): Scientific