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Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction: O-2- vs. N-1-Alkylation

Title
Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction: O-2- vs. N-1-Alkylation
Type
Article in International Scientific Journal
Year
2010
Authors
quezada, elias
(Author)
FCUP
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vina, dolores
(Author)
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delogu, giovanna
(Author)
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borges, fernanda
(Author)
FCUP
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santana, lourdes
(Author)
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uriarte, eugenio
(Author)
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Journal
Vol. 93
Pages: 309-313
ISSN: 0018-019X
Publisher: Wiley-Blackwell
Other information
Authenticus ID: P-003-B34
Abstract (EN): The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Chemical evidences for an unusual competitive O-2- vs. N-1-alkylation of 3-substituted pyrimidines is presented.
Language: English
Type (Professor's evaluation): Scientific
Contact: mdolores.vina@usc.es
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