Synthesis and NMR studies of novel chromone-2-carboxamide derivatives

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Alexandra Gaspar (Author) Other; Fernando Cagide (Author) FCUP; Elias Quezada (Author) FCUP; Joana Reis (Author) Other; Eugenio Uriarte (Author) Other; Fernanda Borges (Author) FCUP

Journal

Title: Organic Magnetic Resonance

Vol. 51

ISSN: 0749-1581

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 7 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-005-1R1

Abstract (EN): Chromones are heterocyclic compounds of natural or synthetic origin that possess relevant pharmacological activities. Versatile functionalization of the chromone nucleus allows attaining of a chemical diversity suitable to perform structure-activity relationships in drug discovery and development programs. Accordingly, the synthesis and identification of novel chromone carboxamide derivatives with electron-donating and electron-withdrawing substituents in different positions of the exocyclic ring are reported in this work. Their complete structural characterization was performed using one-dimensional and two-dimensional resonance techniques. The data acquired are useful for a prompt analysis of related compounds that encompass our integrated medicinal chemistry sketch. Copyright (C) 2013 John Wiley & Sons, Ltd.

Language: English

Type (Professor's evaluation): Scientific