Voltammetric oxidation of drugs of abuse - I. Morphine and metabolites

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Garrido, Jorge M P J (Author) Other; Delerue-Matos, C. M Delerue (Author) Other; Borges, Fernanda Fernanda M (Author) FFUP; Macedo, Tice Reis A (Author) Other; Oliveira-Brett, A. M. (Author) Other

Journal

Title: Electroanalysis

Vol. 16

Pages: 1419-1426

ISSN: 1040-0397

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 46 Citations

Scopus - 48 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Physical sciences > Chemistry

Other information

Authenticus ID: P-000-8NQ

DOI: 10.1002/elan.200302966

Abstract (EN): A detailed study of the electrochemical oxidative behavior of morphine in aqueous solution is reported. Through the synthesis of several metabolites and derivatives, pseudomorphine, morphine N-oxide, normorphine, dihydromorphine and 2-(N,N-dimethylaminomethyl)morphine, and their voltammetric study it was possible to identify the oxidation peaks for morphine. The anodic waves are related with the oxidation of phenolic and tertiary amine groups. It is also possible to verify that a poorly defined peak observable during morphine oxidation is not a consequence of further oxidation of pseudomorphine but due to formation of a dimer during phenolic group oxidation. The results obtained and especially those regarding the formation of a new polymer based on a C-O coupling could be useful for clarifying the discoloration phenomenon occurring during storage of morphine solutions as well as leading to a better understanding of its oxidative metabolic pathways.

Language: English

Type (Professor's evaluation): Scientific