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A route to selective functionalization of polyhydroxypyrrolidines

Title
A route to selective functionalization of polyhydroxypyrrolidines
Type
Article in International Scientific Journal
Year
2012
Authors
Carlos A D Sousa
(Author)
Other
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Fabio Rizzo Aguiar
(Author)
Other
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Xerardo Garcia Mera
(Author)
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Olga Caamano
(Author)
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Jose E Rodriguez Borges
(Author)
FCUP
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Journal
Title: Tetrahedron LettersImported from Authenticus Search for Journal Publications
Vol. 53
Pages: 1029-1032
ISSN: 0040-4039
Publisher: Elsevier
Scientific classification
FOS: Natural sciences > Chemical sciences
Other information
Authenticus ID: P-002-CY3
Abstract (EN): A route to selective functionalization of polyhydroxypyrrolidines is described. The method is based on orthogonal protection/deprotection along the process of synthesis of the referred pyrrolidines, which consist in hydroxylation of the double bond of 2-azabicyclo[2.2.1]hept-5-enes followed by its oxidative cleavage and in situ reduction of the intermediate dialdehyde. The synthesis of a novel N-hydroxypyrrolidine is also described.
Language: English
Type (Professor's evaluation): Scientific
Contact: jrborges@fc.up.pt
No. of pages: 4
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