Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Maria Joao Gouveia (Author) Other; Paul J Brindley (Author) Other; Lucio Lara Santos (Author) ICBAS; Jose Manuel C Correia da Costa (Author) Other; Paula Gomes (Author) FCUP; Nuno Vale (Author) FCUP

Journal

Title: Metabolism: Clinical and Experimental

Vol. 62

Pages: 1206-1217

ISSN: 0026-0495

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 52 Citations

Scopus - 53 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-006-7NE

DOI: 10.1016/j.metabol.2013.04.003

Abstract (EN): Mass spectrometric approaches have been fundamental to the identification of metabolites associated with steroid hormones, yet this topic has not been reviewed in depth in recent years. To this end, and given the increasing relevance of liquid chromatography-mass spectrometry (LC-MS) studies on steroid hormones and their metabolites, the present review addresses this subject. This review provides a timely summary of the use of various mass spectrometry-based analytical techniques during the evaluation of steroidal biomarkers in a range of human disease settings. The sensitivity and specificity of these technologies are clearly providing valuable new insights into breast cancer and cardiovascular disease. We aim to contribute to an enhanced understanding of steroid metabolism and how it can be profiled by LC-MS techniques. Crown Copyright

Language: English

Type (Professor's evaluation): Scientific