N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Vale Costa, S (Author) Other; Costa Gouveia, J (Author) Other; Perez, B (Author) Other; Silva, T (Author) Other; Teixeira, C (Author) Other; Gomes, P (Author) FCUP; Gomes, MS (Author) ICBAS

Journal

Title: Antimicrobial Agents and Chemotherapy

Vol. 57

Pages: 5112-5115

ISSN: 0066-4804

Publisher: American Society for Microbiology

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 13 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-006-6Z9

DOI: 10.1128/aac.00557-13

Abstract (EN): A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.

Language: English

Type (Professor's evaluation): Scientific