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PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

Title
PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
Type
Article in International Scientific Journal
Year
2012
Authors
Bianca Perez
(Author)
Other
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Catia Teixeira
(Author)
FCUP
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Ines S Albuquerque
(Author)
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Jiri Gut
(Author)
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Philip J Rosenthal
(Author)
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Miguel Prudencio
(Author)
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Paula Gomes
(Author)
FCUP
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Journal
Title: MedChemCommImported from Authenticus Search for Journal Publications
Vol. 3
Pages: 1170-1172
ISSN: 2040-2503
Scientific classification
FOS: Natural sciences > Chemical sciences
Other information
Authenticus ID: P-002-5RY
Abstract (EN): Novel primaquine derivatives, obtained by conjugation of the drug's aliphatic amine with different cinnamic acids, resulted in increased in vitro activity, compared to primaquine, against liver-stage malarial parasites. The compounds were non-cytotoxic to human hepatoma cells, suggesting that they are a promising new class of agents for the treatment and prevention of malaria.
Language: English
Type (Professor's evaluation): Scientific
License type: Click to view license CC BY-NC
Documents
File name Description Size
ART_70 163.46 KB
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