LOSS OF Y-CHROMOSOME IN GASTRIC-CARCINOMA - FACT OR ARTIFACT

• Type: Article in International Scientific Journal
• Date: 1992

Authors

CASTEDO, S (Author) FMUP; CORREIA, C (Author) Other; SERUCA, R (Author) Other; SOARES, P (Author) Other; CARNEIRO, F (Author) FMUP; SOBRINHOSIMOES, M (Author) FMUP

Journal

Title: Cancer Genetics and Cytogenetics

Vol. 61

Pages: 39-41

ISSN: 0165-4608

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 19 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-001-PD7

DOI: 10.1016/0165-4608(92)90367-h

Abstract (EN): Loss of chromosome Y has been reported in gastric cancer cells together with other chromosomal abnormalities. We noted loss of chromosome Y and near-diploid karyotypes in five cases of gastric adenocarcinoma, but DNA flow cytometry performed on fresh tumor tissue showed aneuploid peaks in four of them. Our findings suggest that loss of the Y chromosome in gastric cancer probably reflects the karyotype of a subpopulation of stromal cells and not a neoplasia-related chromosomal aberration.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3