Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Nuno Vale (Author) FCUP; Margaret S Collins (Author) Other; Jiri Gut (Author) Other; Ricardo Ferraz (Author) Other; Philip J Rosenthal (Author) Other; Melanie T Cushionc (Author) Other; Rui Moreira (Author) Other; Paula Gomes (Author) FCUP

Journal

Title: Bioorganic and Medicinal Chemistry Letters

Vol. 18

Pages: 485-488

ISSN: 0960-894X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 36 Citations

Scopus - 34 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-21G

DOI: 10.1016/j.bmcl.2007.11.105

Abstract (EN): A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 mu g/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the mu M range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead compound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.

Language: English

Type (Professor's evaluation): Scientific