Characterization of primaquine imidazolidin-4-ones with antimalarial activity by electrospray ionization-ion trap mass spectrometry

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Nuno Vale (Author) FCUP; Rui Moreira (Author) Other; Paula Gomes (Author) FCUP

Journal

Title: International Journal of Mass Spectrometry

Vol. 270

Pages: 81-93

ISSN: 1387-3806

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 8 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-1GB

DOI: 10.1016/j.ijms.2007.12.006

Abstract (EN): The extensive characterization by electrospray ionization-ion trap mass spectrometry (ESI-MS(n)) of 20 imidazolidin-4-ones derived from the antimalarial primaquine was well obtained. These compounds are being under investigation as potential antimalarials, as they have been previously found to be active against rodent P. berghei malaria and to be highly stable under physiological conditions. Experiments by collision-induced dissociation (CID) in the nozzle-skimmer region or by tandem-MS have shown the title compounds to be remarkably stable. Mechanisms are proposed to explain the major fragmentations observed in ESI-MS(n) experiments. Overall, this work represents an unprecedented contribution to a deeper insight into imidazolidin-4-one antimalarials based on a classic 8-aminoquinolinic scaffold. Data herein reported and discussed may be an useful guide for future studies on therapeutically relevant molecules possessing either the 8-aminoquinoline or the imidazolidin-4-one motifs.

Language: English

Type (Professor's evaluation): Scientific