Amino acid/water interactions study: a new amino acid scale

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Pedro P. Madeira (Author) FEUP; Ana Bessa (Author) FEUP; Luís Álvares Ribeiro (Author) FCUP; M. Raquel R. Aires Barros (Author) Other; Alírio E. Rodrigues (Author) FEUP; Vladimir N. Uversky (Author) Other; Boris Y. Zaslavsky (Author) Other

Journal

Title: Journal of Biomolecular Structure and Dynamics

Vol. 32 No. 6

Pages: 959-968

ISSN: 0739-1102

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 33 Citations

Scopus - 37 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Associated Projects

LA 20 - PROJECTO ESTRATÉGICO - LA 20 - 2013-2014

Other information

Authenticus ID: P-008-NEP

DOI: 10.1080/07391102.2013.800994

Abstract (EN): Partition ratios of 8 free l-amino acids (Gln, Glu, His, Lys, Met, Ser, Thr, and Tyr) were measured in 10 different polymer/polymer aqueous two-phase systems containing 0.15 M NaCl in 0.01 M phosphate buffer, pH 7.4. The solute-specific coefficients representing the solute dipole/dipole, hydrogen-bonding and electrostatic interactions with the aqueous environment of the amino acids were determined by multiple linear regression analysis using a modified linear solvation energy relationship. The solute-specific coefficients determined in this study together with the solute-specific coefficients reported previously for amino acids with non-polar side-chains where used in a Quantitative Structure/Property Relationship analysis. It is shown that linear combinations of these solute-specific coefficients are correlated well with various physicochemical, structural, and biological properties of amino acids.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10