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Techniques to Investigate Neuronal Mitochondrial Function and its Pharmacological Modulation

Title
Techniques to Investigate Neuronal Mitochondrial Function and its Pharmacological Modulation
Type
Another Publication in an International Scientific Journal
Year
2011
Authors
Journal
Title: Current Drug TargetsImported from Authenticus Search for Journal Publications
Vol. 12 No. 6
Pages: 762-773
ISSN: 1389-4501
Publisher: Bentham Science
Scientific classification
FOS: Medical and Health sciences > Basic medicine
Other information
Authenticus ID: P-002-QQT
Abstract (EN): Mitochondria are central regulators of neuronal homeostasis and survival, and increasingly viewed as a drug target in several acute and chronic neurological disorders, e. g. stroke, Alzheimer's, Parkinson's, and Huntington's diseases. Frequent working hypotheses aim to establish whether and how chemical or genetic lesions affect mitochondrial function in neurons, and whether this can be rescued by pharmacological treatments. However, the generic designation 'mitochondrial function' actually encompasses a wide spectrum of individual activities, too numerous to be fully quantified by any single available technique. This review aims to provide a broad perspective on the roles played by neuronal mitochondria, and addresses multiple techniques that can be used to derive instructive functional indicators. These include measurements of mitochondrial respiration, ATP production, membrane potential, calcium handling, biogenesis, dynamic movement as well as fusion and fission. Technique descriptions are preceded by a summary of mitochondrial physiology and pharmacological tools required for functional modulation and parameter determination. Hopefully, these will assist researchers interested in testing mitochondria as a drug target in neurological disease models.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 12
Documents
File name Description Size
Review_CDT_Accepted Version After Embargo ACCEPTED VERSION after 12 MONTHS of publication 1985.31 KB
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