Study of organic compounds-water interactions by partition in aqueous two-phase systems

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Pedro P Madeira (Author) Other; Ana Bessa (Author) Other; Miguel A Teixeira (Author) FEUP; Luis Alvares Ribeiro (Author) FCUP; Raquel Aires Barros, MR (Author) Other; Alirio E Rodrigues (Author) FEUP; Boris Y Zaslavsky (Author) Other

Journal

Title: Journal of Chromatography A

Vol. 1322

Pages: 97-104

ISSN: 0021-9673

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 16 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-006-J3K

DOI: 10.1016/j.chroma.2013.10.085

Abstract (EN): Partition coefficients of fourteen organic compounds were determined in 10 or 20 different polymer/polymer aqueous two-phase systems (ATPS) all at physiological pH (0.15 M NaCl in 0.01 M phosphate buffer, pH 7.4). Solute-specific coefficients characterizing different types of solute-water interactions for the compounds examined were determined by the multiple linear regression analysis. It is shown that (i) the partition behavior for the polar organic compounds is affected not only by dipole-dipole and hydrogen-bond interactions with aqueous environment but, notably, in most cases also by dipole-ion interactions; (ii) it is possible to predict partition behavior for compounds with pre-determined solutespecific coefficients in ATPS with characterized solvent features; and (iii) linear combinations of the solute-specific coefficients for the organic compounds might be useful in the development of quantitative structure-activity relationship (QSAR) analysis to describe their odor detection threshold.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8