Virulence of Mycobacterium avium in mice does not correlate with resistance to nitric oxide

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Susana Lousada (Author) Other; Manuela Florido (Author) Other; Rui Appelberg (Author) ICBAS

Journal

Title: Microbial Pathogenesis

Vol. 43

Pages: 243-248

ISSN: 0882-4010

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-004-6M4

DOI: 10.1016/j.micpath.2007.06.003

Abstract (EN): The growth in C57Bl/6 mice of seven distinct Mycobacterium avium strains was not exacerbated by the disruption of the inducible (type 2) nitric oxide synthase regardless of the virulence of the strain. The susceptibility of this panel of M. avium strains to reactive nitrogen intermediates in a cell-free system, namely the exposure to acidified nitrite or to the NO donor NOG 18, showed that there is no correlation between strain virulence and the corresponding minimal bactericidal and minimal inhibitory concentrations for those compounds determined in vitro.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6