An Immunohistochemical Study of Feline Endometrial Adenocarcinoma

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Rui Oliveira (Author) ICBAS; Marta Susana Santos (Author) ICBAS; Irina Amorim (Author) ICBAS; Célia Lopes (Author) ICBAS; Patricia Dias Pereira (Author) ICBAS; Augusto Faustino (Author) ICBAS

Journal

Title: Journal of Comparative Pathology

Vol. 140 No. 140

Pages: 254-259

ISSN: 0021-9975

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 14 Citations

Pubmed / Medline

Scientific classification

FOS: Agrarian Sciences > Veterinary science

Other information

Authenticus ID: P-003-KET

DOI: 10.1016/j.jcpa.2008.12.006

Abstract (EN): Feline endometrial adenocarcinomas are Uncommon malignant neoplasms that have to date been poorly characterized. The present immunohistochemical study describes the expression of the pancytokeratins AE1 and AE3, cytokeratin-14. vimentin, alpha-actin, cyclo-oxygenase-2, E-cadherin, beta-catenin, the progesterone receptor, the oestrogen receptor and caveolin-1 within normal feline uterine tissue and tissue from six cats with endometrial adenocarcinoma. Synthesis of cyclo-oxygenase-2 and reduced expression of progesterone receptors may be involved in the neoplastic transformation of feline endometrium. The loss Of Cellular adhesion that occurs within these tumours does not require down-regulation of E-cadherin expression and nuclear translocation of beta-catenin is not a feature of these neoplasms.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6