COX-2 Expression in Canine Normal and Neoplastic Mammary Gland

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Dias D Pereira (Author) Other; Lopes, CC (Author) Other; Matos, AJF (Author) ICBAS; Santos, M (Author) Other; Gaertner, F (Author) Other; Medeiros, R (Author) ICBAS; Lopes, C (Author) ICBAS

Journal

Title: Journal of Comparative Pathology

Vol. 140 No. 140

Pages: 247-253

ISSN: 0021-9975

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 30 Citations

Scopus - 33 Citations

Pubmed / Medline

Scientific classification

FOS: Agrarian Sciences > Veterinary science

Other information

Authenticus ID: P-003-KES

DOI: 10.1016/j.jcpa.2008.12.005

Abstract (EN): COX-2 expression was examined immunohistochemically in samples of normal canine mammary tissue (n = 22) and benign (n= 36) and malignant (n = 45) mammary tumours including metastases (n = 12). COX-2 was constitutively expressed in normal mammary tissue with membranous apical labelling of glandular epithelium, suggesting a role for this molecule in normal mammary physiology. By contrast, in neoplastic lesions and in adjacent non-neoplastic mammary tissue COX-2 was expressed in the cytoplasm of epithelial cells, suggesting that internalization of the molecule is associated with oncogenesis. Marked expression of COX-2 was observed in 8.3% of benign neoplasms and in 42.2% of malignant neoplasms, mainly in poorly differentiated areas. The majority of metastatic lesions (58.3%) exhibited strong COX-2 labelling and in almost all cases (83.3%) the labelling intensity was similar or stronger to that of the primary neoplasm. This finding is consistent with the hypothesis that COX-2 metabolites are important promoters of angiogenesis and invasiveness and therefore contribute to metastatic spread.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7