Expression of E-cadherin in normal, hyperplastic and neoplastic feline mammary tissue

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Patricia Dias Pereira (Author) ICBAS; Fátima Gartner (Author) ICBAS

Journal

Title: Veterinary Record

Vol. 153

Pages: 297-302

ISSN: 0042-4900

Publisher: Wiley-Blackwell

Indexing

Pubmed / Medline

Scientific classification

FOS: Agrarian Sciences > Veterinary science

Other information

Authenticus ID: P-000-F63

Abstract (EN): This paper describes an immunohistochemical study of the expression of E-cadherin in four samples of normal, eight samples of hyperplastic and 19 samples of neoplastic feline mammary tissue. In the normal tissues, the luminal epithelial cells showed a strong pattern of staining for E-cadherin at the cell-cell boundaries, whereas the myoepithelium showed no immunoreactivity. In the hyperplastic tissues and the five benign neoplasms, there were disturbances in the expression of E-cadherin in the luminal epithelium, in the form of the coexistence of membranous and cytoplasmic staining, together with immunoreactivity in a small percentage of myoepithelial cells. In 11 of 14 carcinomas, there was a reduction or absence of E-cadherin expression and abnormalities in the pattern of immunostaining; these changes were more pronounced in cribriform and solid carcinomas.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10