Secretory carcinoma of the canine mammary gland

• Type: Article in International Scientific Journal
• Date: 1999

Authors

Cassali, GD (Author) Other; Gobbi, H (Author) Other; Fátima Gärtner (Author) ICBAS; Fernando Schmitt (Author) Other

Journal

Title: Veterinary Pathology

Vol. 36

Pages: 601-603

ISSN: 0300-9858

Publisher: SAGE

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 12 Citations

Pubmed / Medline

Scientific classification

FOS: Agrarian Sciences > Other Agrarian Sciences

Other information

Authenticus ID: P-008-P5R

DOI: 10.1354/vp.36-6-601

Abstract (EN): Secretory carcinoma is an uncommon variant of breast cancer, characterized by the presence of intracellular and extracellular eosinophilic secretion. Here, we report the cytologic, histologic, and immunohistochemical findings of a secretory carcinoma diagnosed in the left inguinal mammary gland of a 3-year-old female German Shepherd Dog. The fine-needle aspiration cytology showed numerous large branching sheets of neoplastic cells and isolated cells with cytoplasmic vacuoles. Histologically, the tumor was composed of cells with clear cytoplasm and prominent vacuoles that pushed the nuclei to the periphery, resembling signet ring cells. These cells were arranged in solid or tubular structures with lumenal spaces filled with eosinophilic secretion. Immunohistochemical reactions to cytokeratin (CAM 5.2) and alpha-lactalbumin were strongly positive in all neoplastic cells, and staining for vimentin and S100 protein was negative. The cytomorphologic and immunohistochemical features of this tumor are similar to those seen in tumors in women, hence enabling the diagnosis of a rare case of primary secretory carcinoma of the canine mammary gland.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3