Lobar brain hemorrhages and white matter changes: Clinical, radiological and laboratorial profiles

• Type: Article in International Scientific Journal
• Date: 2006

Authors

maia, lf (Author) Other; vasconcelos, c (Author) Other; seixas, s (Author) Other; Magalhaes, R (Author) ICBAS; correia, m (Author) Other

Journal

Title: Cerebrovascular Diseases

Vol. 22 No. 2

Pages: 155-161

ISSN: 1015-9770

Publisher: Karger

Indexing

ISI Web of Knowledge - 23 Citations

ISI Web of Science

Scopus - 27 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-004-PA5

DOI: 10.1159/000093245

Abstract (EN): Background: White matter changes have several histopathologic correlates including cerebral amyloid angiopathy ( CAA). The aim of this study was to characterize the clinical, laboratorial and neuroradiological profile of a CAA- related lobar hemorrhages case series. Methods: A cohort of 50 consecutive patients with cerebral lobar hemorrhages was studied and clinical, radiological data and ApoE polymorphisms were analyzed. White matter changes were graded and microbleeds were characterized according to number and location using T-2* MRI. Results: A statistically significant association was found between the prestroke cognitive performance and poststroke dementia and between hemorrhage volume and mortality. More severe white matter changes were found in probable CAA when comparing to possible CAA. The most prominent white matter lesions are associated with the presence and the number of microbleeds. The frequency of APOE epsilon 2 and epsilon 4 alleles was higher in this cohort when compared to a Northern Portuguese population. Conclusion: White matter changes are frequent in lobar hemorrhage patients and are associated with cortical microbleeds, the radiological hallmark of CAA. Therefore, white matter changes may be the sole phenotype of CAA and, potentially, involved in the pre-stroke cognitive impairment presented by the patients, which are genetically distinct from the population in general. Copyright (c) 2006 S. Karger AG, Basel

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7