Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Raquel Catarino (Author) Other; Ana Coelho (Author) Other; Antonio Araujo (Author) Other; Monica Gomes (Author) Other; Augusto Nogueira (Author) Other; Carlos Lopes (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: PLoS ONE

Vol. 7 No. 4

Final page: e38559

ISSN: 1932-6203

Publisher: Public Library of Science

Indexing

ISI Web of Knowledge - 55 Citations

Scopus - 54 Citations

Pubmed / Medline

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-002-90E

DOI: 10.1371/journal.pone.0038559

Resumo (PT): PURPOSE: The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease. METHODS: We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology. RESULTS: We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations. CONCLUSIONS: Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.

Abstract (EN): Purpose: The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease. Methods: We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology. Results: We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations. Conclusions: Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8