Host defense mechanisms in invasive candidiasis originating in the GI tract

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Manuel Vilanova (Author) ICBAS; Alexandra Correia (Author) ICBAS

Journal

Title: Expert Review of Anti-Infective Therapy

Vol. 6 No. 4

Pages: 441-445

ISSN: 1478-7210

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 4 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-X92

DOI: 10.1586/14787210.6.4.441

Abstract (EN): Candida spp. rank among the leading causative agents of nosocomial infections. The increasing number of patients at risk of invasive candidiasis makes a rise in the incidence of this fungal infection expected. Disruption of GI tract integrity and ablation of immune cell populations, such as those resulting from cancer chemotherapy, are recognized as key factors leading to fungal dissemination. However, the individual role of these immune barriers in preventing Candida host colonization and invasion are yet to be fully understood. This article evaluates recently published results on a new murine model of systemic candidiasis originating in the GI tract that might prove a valuable setting for the accurate study of host immune mechanisms, fungal virulence factors and novel therapeutic approaches.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5