Genetic control of immune-mediated necrosis of Mycobacterium avium granulomas

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Florido, M (Author) Other; Appelberg, R (Author) ICBAS

Journal

Title: Immunology

Vol. 118

Pages: 122-130

ISSN: 0019-2805

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 10 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences > Medical sciences > Medicine > Infections

Other information

Authenticus ID: P-004-KYM

DOI: 10.1111/j.1365-2567.2006.02350.x

Abstract (EN): Intravenous infection of C57BL/6 and C57BL/10 mice with low doses of a highly virulent strain of Mycobacterium avium (ATCC 25291) led to the development of granulomas that underwent necrosis. In contrast, neither BALB/c nor DBA/1 mice developed granuloma necrosis after such infection despite a similar course of mycobacterial proliferation. Studies with C57BL/10 mice congenic for the Hc locus revealed that an intact complement C5 gene is required for granuloma necrosis. On the other hand, genetic disruption of the interleukin-10 gene in BALB/c mice made this strain susceptible to granuloma necrosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9