Troponin I, but not BNP, is Associated with Phosphorus, Calcium and Vitamin D in Stable Coronary Artery Disease

• Type: Article in International Scientific Journal
• Date: 2013

Authors

José Pedro L. Nunes (Author) FMUP

Journal

Title: Kidney and Blood Pressure Research

Vol. 37

Pages: 43-47

ISSN: 1420-4096

Publisher: Karger

Indexing

ISI Web of Knowledge - 2 Citations

ISI Web of Science

Scopus - 4 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-005-3D7

DOI: 10.1159/000343399

Abstract (EN): Background: Elevated plasma cardiac troponin, elevated plasma phosphorus and decreased plasma vitamin D have been shown to be associated with negative outcomes. Methods and results: Troponin I, calcium, phosphorus and 25-OH vitamin D were studied in a cohort of 60 patients with stable coronary heart disease and preserved left ventricular function. Using a cut-off value of 0.012 ng/mL for plasma troponin I, patients with higher values (18 patients), when compared to the other patients (n=42), had higher mean values for plasma phosphorus (3.42 +/- 0.45 mg/dL vs 3.17 +/- 0.45 mg/dL, p = 0.041) and calcium (5.08 +/- 0.23 mEq/L vs 4.92 +/- 0.18 mEq/L, p= 0.016) and lower values for 25-OH vitamin D (14.2 +/- 5.6 ng/mL vs 19.4 +/- 8.8 ng/mL, p= 0.032). Binary logistic regression analysis showed that troponin I > 0.012 ng/ml is associated with increased phosphorus, increased calcium and decreased 25-OH vitamin D concentrations. A similar analysis using BNP > 100 pg/mL failed to show significant associations with phosphorus, calcium and 25-OH vitamin D concentrations. Conclusions: In patients with stable coronary artery disease and preserved left ventricular function, those having cardiac troponin I > 0.012 ng/ml, but not those having BNP > 100 pg/mL, had higher plasma phosphorus, higher plasma calcium and lower plasma 25-OH vitamin D concentrations than those having cardiac troponin I <= 0.012 ng/ml (or BNP <= 100 pg/mL).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5