Comparison of different methods of heart rate entropy analysis during acute anoxia superimposed on a chronic rat model of pulmonary hypertension

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Hernani Goncalves (Author) FCUP; Tiago Henriques Coelho (Author) FMUP; Ana Paula Rocha (Author) FCUP; Andre P Lourenco (Author) FMUP; Adelino Leite Moreira (Author) FMUP; Joao Bernardes (Author) FMUP

Journal

Title: Medical Engineering & Physics

Vol. 35 No. 12

Pages: 559-568

ISSN: 1350-4533

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 6 Citations

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

Other information

Authenticus ID: P-005-163

DOI: 10.1016/j.medengphy.2012.06.020

Abstract (EN): Acute life-threatening situations are particularly critical when superimposed on chronic diseases. The objective of this study was the assessment of heart rate (HR) dynamics during episodes of acute anoxia superimposed on a rat model of chronic pulmonary hypertension. In 10 adult Wistar rats, five weeks after pulmonary hypertension induction with Monocrotaline, we analysed eight 1-min HR segments, during episodes of baseline, mechanical ventilation and acute anoxia, using linear indices, approximate entropy (ApEn), sample entropy (SampEn) and multiscale entropy (MSE). The transition from baseline or mechanical ventilation to early anoxia was identified through almost all indices, but SampEn(2,0.6) was the index that better identified all the transitions. MSE presented limited performance, possibly due to the non-stationary nature and short duration of the acute anoxia episodes. A systematic evaluation of all computed HR indices may help to identify which indices or combination of indices more adequately discriminates and monitors critical acute events superimposed on chronic clinical conditions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10