Nonpigmented fixed drug eruption induced by esomeprazole

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Morais P (Author) FMUP; Baudrier T (Author) Other; Mota A (Author) FMUP; Cunha AP (Author) Other; Cadinha S (Author) Other; Barros AM (Author) Other

Journal

Title: Cutaneous and Ocular Toxicology

Vol. 29 No. 3

Pages: 217-220

ISSN: 1556-9527

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 15 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-003-37B

DOI: 10.3109/15569527.2010.484824

Abstract (EN): A 56-year-old white woman developed a distinctive skin eruption over her mammary, lumbosacral, and pubic areas 2 weeks after the start of esomeprazole therapy for dyspeptic symptoms. Skin biopsy disclosed a spongiotic dermatitis with predominantly lymphocytic dermal infiltrate. Treatment with a tapering dose of corticosteroid and withdrawal of the suspected drug led to a rapid resolution of the eruption without residual dyschromia. Patch testing with esomeprazole 2% in petrolatum was negative at 48 and 72 hours but became positive on day 6. Oral-controlled provocation test induced the reappearance of the lesions over the mammary areas, confirming the putative involvement of this drug. Therefore, the patient was diagnosed as having a nonpigmented fixed drug eruption associated with esomeprazole. This compound is a proton-pump inhibitor developed as the S-isomer of omeprazole to improve its pharmacokinetic properties. Reports of cutaneous reactions to proton-pump inhibitors are quite common, but reports of such reactions to esomeprazole are rare, which demonstrates the need for higher clinical awareness and knowledge of reactions to these drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4