Prognostic value of cardiac troponin I in patients with COPD acute exacerbation

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Carla S. Martins (Author) FMUP; Mariana J. Rodrigues (Author) Other; Vasco P. Miranda (Author) Other; José Pedro L. Nunes (Author) FMUP

Journal

Title: Netherlands Journal of Medicine

Vol. 67

Pages: 341-349

ISSN: 0300-2977

Publisher: Van Zuiden Communications BV

Indexing

ISI Web of Knowledge - 40 Citations

Scopus - 40 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-003-EV1

Abstract (EN): Background: Chronic obstructive pulmonary disease (COPD) is frequently associated with right ventricular loading and pulmonary hypertension. We aimed to evaluate a possible association between cardiac troponin I (cTnI) levels and adverse events in hospitalised patients with acute exacerbation of COPD. Methods: Retrospective cohort study, with analysis of admissions for acute exacerbation of COPD, with cTnI obtained in the first 48 hours of admission. A positive cTnI test was defined as 0.012 ng/ml or higher (99th percentile). Baseline and peak troponin I levels were taken as independent variables, and outcome variables included length of hospital stay, complications during hospitalisation, and in-hospital and extra-hospital mortality (evaluated 18 months post-discharge). Results: Data concerned 173 patients (105 male, 68 female), with a median age Of 77 years (interquartile range of II years). The median baseline cTnI was 0.030 ng/ml (n=173), and the median peak cTnI was 0.040 ng/ml (n=173; absolute peak value of 1.260 ng/ml). Nearly 70% of cases had a positive cTnI at admission. Both baseline and peak cTnI correlated significantly with the need for noninvasive ventilatory support. We were not able to find significant differences in in-hospital survival associated with the two troponin groups, but overall 18-month survival was significantly higher among patients with lower values of baseline and peak cTnI. Conclusions: In patients hospitalised for acute COPD exacerbations, elevated baseline and peak cTnI were associated with a greater need for noninvasive ventilatory support and were significant predictors of 18-month overall survival.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9