Deep brain stimulation does not change neurovascular coupling in non-motor visual cortex An autonomic and visual evoked blood flow velocity response study

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Elsa Azevedo (Author) FMUP; Rosa Santos (Author) Other; Joao Freitas (Author) FMUP; Maria Jose Rosas (Author) Other; Miguel Gago (Author) Other; Carolina Garrett (Author) FMUP; Bernhard Rosengarten (Author) Other

Journal

Title: Parkinsonism and Related Disorders

Vol. 16 No. 9

Pages: 600-603

ISSN: 1353-8020

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 14 Citations

ISI Web of Science

Scopus - 19 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

CORDIS: Health sciences > Neuroscience > Neurology

Other information

Authenticus ID: P-003-1MR

DOI: 10.1016/j.parkreldis.2010.08.016

Abstract (EN): Background and Purpose In Parkinson s disease (PD) subthalamic nucleus deep brain stimulation (STN-DBS) improves motor function Also an effect on the neurovascular coupling in motor cortex was reported due to a parallel activation of a subthalamic vasodilator area (SVA) To address this issue further we analysed neurovascular coupling in a non-motor area Methods Twenty PD patients selected for bilateral STN-DBS were investigated with functional transcranial Doppler (f-TCD) before and after surgery Hemodynamic responses to visual stimulation were registered in left posterior cerebral artery (PCA) and analysed with a control-system approach (parameters gain rate time attenuation and natural frequency) To exclude autonomic effects of STN-DBS we also addressed spectrum analysis of heart rate and of systolic arterial blood pressure variability and baroreceptor gain Findings in the PD group were compared with healthy age-matched controls Results PD patients showed no neurovascular coupling changes in PCA territory compared to controls and STN-DBS changed neither blood flow regulatory parameters nor autonomic function Conclusions Improvement of vasoregulation in some motor cortical areas after STN-DBS might be related to an Improved neuronal functional rather than indicating an effect on the neurovascular coupling or autonomic function

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4