Beat-to-beat modulation of right and left ventricular positive dP/dt by afterload Implications for the evaluation of inotropy

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Correia-Pinto, J (Author) Other; Leite-Moreira, AF (Author) FMUP; Henriques-Coelho, T (Author) FMUP; Magalhães, S (Author) Other; Gillbert, TC (Author) Other

Journal

Title: Acta Cardiologica

Vol. 58 No. 4

Pages: 327-334

ISSN: 0001-5385

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 2 Citations

ISI Web of Science

Scopus - 2 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences

Other information

Authenticus ID: P-000-FK9

DOI: 10.2143/ac.58.4.2005290

Abstract (EN): Objectives - The rate of pressure rise (dP/dt(max)) has mainly been studied in the left ventricle (LV), where it was demonstrated to be highly dependent of preload, but independent of afterload. Load dependence of right ventricular (RV) dP/dt(max) is assumed to be similar to (LV)dP/dt(max), although this issue has not yet been investigated in detail. In the current study, we evaluated acute afterload dependence of dP/dt(max) in both ventricles in rats. Methods and results - Adult Wistar rats (n = 8) were instrumented to record RV and W pressures and septal-free wall diameters. RV and W afterload elevations were performed by beat-to-beat graded constrictions of the pulmonary trunk or aortic root, respectively. Control cycles and low, moderate and high (isovolumetric) afterload levels were analysed. In both ventricles, afterload modulation of dP/dt was assessed by dP/dt(max) normalized for end-diastolic dimensions (dP/dt(max)/EDD) and by peak and mean accelerations of pressure rise. RV afterload elevation increased dP/dt(max), dP/dt(max)/EDD, peak and mean acceleration of RV pressure rise, without changing the time from end-diastole to dP/dt(max). LV afterload elevations did not significantly change the corresponding left-sided parameters. Conclusions - In this study we demonstrated that, in contrast to the left ventricle, right ventricular dP/dt(max) and dP/dt(max)/EDD relation are significantly afterload sensitive. This should be taken into account for its application in the haemodynamic evaluation of cardiac function in experimental and clinical settings.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10