Moderate exercise training provides left ventricular tolerance to acute pressure overload

• Type: Article in International Scientific Journal
• Date: 2011

Authors

moreira-goncalves, d (Author) Other; henriques-coelho, t (Author) FMUP; fonseca, h (Author) Other; ferreira, rm (Author) Other; amado, f (Author) Other; leite-moreira, a (Author) FMUP; duarte, ja (Author) FADEUP

Journal

Title: American Journal of Physiology - Heart and Circulatory Physiology

Vol. 300 No. 3

Pages: H1044-H1052

ISSN: 0363-6135

Publisher: American Physiological Society

Indexing

ISI Web of Knowledge - 12 Citations

ISI Web of Science

Scopus - 12 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-002-TNW

DOI: 10.1152/ajpheart.01008.2010

Abstract (EN): Moreira-Goncalves D, Henriques-Coelho T, Fonseca H, Ferreira RM, Amado F, Leite-Moreira A, Duarte JA. Moderate exercise training provides left ventricular tolerance to acute pressure overload. Am J Physiol Heart Circ Physiol 300: H1044-H1052, 2011. First published December 24, 2010; doi: 10.1152/ajpheart.01008.2010.-The present study evaluated the impact of moderate exercise training on the cardiac tolerance to acute pressure overload. Male Wistar rats were randomly submitted to exercise training or sedentary lifestyle for 14 wk. At the end of this period, the animals were anaesthetized, mechanically ventilated, and submitted to hemodynamic evaluation with biventricular tip pressure manometers. Acute pressure overload was induced by banding the descending aorta to induce a 60% increase of peak systolic left ventricular pressure during 120 min. This resulted in the following experimental groups: 1) sedentary without banding (SED + Sham), 2) sedentary with banding (SED + Band), and 3) exercise trained with banding (EX + Band). In response to aortic banding, SED + Band animals could not sustain the 60% increase of peak systolic pressure for 120 min, even with additional narrowing of the banding. This was accompanied by a reduction of dP/dt(max) and dP/dt(min) and a prolongation of the time constant tau, indicating impaired systolic and diastolic function. This impairment was not observed in EX + Band (P < 0.05 vs. SED + Band). Additionally, compared with SED + Band, EX + Band presented less myocardial damage, exhibited attenuated protein expression of active caspase-3 and NF-kappa B (P < 0.016), and showed less protein carbonylation and nitration (P < 0.05). These findings support our hypothesis that exercise training has a protective role in the modulation of the early cardiac response to pressure overload.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9