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The role of breast MRI in the investigation of anti-Yo positive paraneoplastic cerebellar degeneration

Title
The role of breast MRI in the investigation of anti-Yo positive paraneoplastic cerebellar degeneration
Type
Article in International Scientific Journal
Year
2012
Authors
Real, R
(Author)
Other
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Oliveira, A
(Author)
Other
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Nadais, G
(Author)
Other
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Loureiro, J
(Author)
Other
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Garrett, MC
(Author)
FMUP
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Journal
Title: BMJ Case ReportsImported from Authenticus Search for Journal Publications
Vol. 2012
ISSN: 1757-790X
Indexing
Publicação em ISI Web of Knowledge ISI Web of Knowledge
Publicação em Scopus Scopus - 0 Citations
Scientific classification
CORDIS: Health sciences > Medical sciences > Medicine > Oncology ; Health sciences > Neuroscience > Neurology
Other information
Authenticus ID: P-008-3WA
Abstract (EN): Paraneoplastic neurological syndromes are a group of rare and heterogeneous disorders complicating cancer through immune-mediated mechanisms. They typically arise before the diagnosis of malignancy, thus constituting its first clinical manifestation. A thorough search for the underlying tumour is necessary, as adequate tumour management is essential for both neurological prognosis and overall survival. The authors present the case of a 43 year-old woman who presented with a subacute cerebellar syndrome associated with the paraneoplastic anti-Yo antibody. Although paraneoplastic aetiology was immediately suspected, the diagnosis of the underlying tumour was not straightforward, as is often the case. This case report highlights the importance of directing tumour search for the most probable anatomic locations, according to patient demographics and risk factors as well as the type of onconeural antibodies present, and also the need to use the most sensitive diagnostic modalities appropriate for each target organ. Copyright 2012 BMJ Publishing Group. All rights reserved.
Language: English
Type (Professor's evaluation): Scientific
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