Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Drummond M (Author) Other; Winck JC (Author) FMUP; Guimarães JT (Author) FMUP; Santos AC (Author) FMUP; Almeida J (Author) Other; Marques JA (Author) FMUP

Journal

Title: BMC Pulmonary Medicine

Vol. 8

Initial page: 21

ISSN: 1471-2466

Publisher: Springer Nature

Indexing

Scopus - 24 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-007-NPA

DOI: 10.1186/1471-2466-8-21

Abstract (EN): Background: Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods: Inninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results: In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion: Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels. © 2008 Drummond et al; licensee BioMed Central Ltd.

Language: English

Type (Professor's evaluation): Scientific