Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Fernando Schmitt (Author) FMUP

Journal

Title: International Journal of Gynecological Pathology

Vol. 27

Pages: 568-574

ISSN: 0277-1691

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 88 Citations

Scopus - 89 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences > Medical sciences > Medicine > Pathological anatomy

Other information

Authenticus ID: P-003-VVB

DOI: 10.1097/pgp.0b013e31817b5b40

Abstract (EN): Solid tumor cells are known to be highly glycolytic and, to prevent apoptosis by cellular acidosis. cells increase proton efflux through pH regulators, such as monocarboxylate transporters (MCTs). However, the role of these membrane proteins in solid tumor development and survival is not fully understood. We aimed to evaluate the expression of the MCT isoforms 1, 2, and 4 in a large series of cervical lesions (neoplastic and nonneoplastic) and assess its clinical-pathologic significance. The series analyzed included 29 chronic cervicitis, 30 low-grade squamous intraepithelial lesions, 32 high-grade squamous intraepithelial lesions, 49 squamous cell carcinomas, 51 adenocarcinomas, and 30 adenosquamous carcinomas of the uterine cervix. Analysis of the expression of MCT isoforms 1, 2, and 4 was performed by immunohistochemistry with specific antibodies. Immunoreactions were evaluated both qualitatively and semiquantitatively. We found a significant increase in MCT expression from preinvasive to invasive squamous lesions and from normal andular epithelium to adenocarcinomas. This is the first study evaluating the significance of MCT expression in lesions of the uterine cervix, including invasive carcinomas, and the results found herein led us to believe that these membrane proteins are involved in the progression to invasiveness in uterine cervix carcinoma.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7