The association between the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor-1 gene and deep venous thrombosis in young people

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Mansilha A. (Author) FMUP; Araújo F. (Author) FMUP; Severo M. (Author) FMUP; Sampaio S. (Author) FMUP; Toledo T. (Author) Other; Henriques I. (Author) Other; Roncon Albuquerque R. (Author) FMUP

Journal

Title: Phlebology

Vol. 20 No. 1

Pages: 48-52

ISSN: 0268-3555

Publisher: SAGE

Indexing

Pubmed / Medline

Scientific classification

CORDIS: Health sciences > Medical sciences > Medicine > Surgery

Other information

Abstract (EN): Objectives: To evaluate the association between the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene and deep venous thrombosis (DVT) in young people. Methods: Prevalence of the 4G/5G polymorphism was investigated using DNA analysis in a population of 81 consecutive and unrelated patients with an objectively documented first episode of DVT under 40 years old and in a control group of 88 healthy subjects. Results: The frequency of genotypes among patients was 0.27 4G/4G, 0.49 4G/5G and 0.23 5G/5G, corresponding to a frequency of 0.52 for the 4G allele. In the control group the results were, respectively, 0.24, 0.44 and 0.32, corresponding to a frequency of 0.46 for the 4G allele. The odds ratio (OR) for homozygous 4G genotype was 1,5 (95% confidence interval: 0.7-3.6), which was statistically significant (P = 0.51). Conclusion: In this study, the 4G/5G polymorphism in the promoter of the PAI-1 gene, including the homozygous 4G genotype, was not associated with a significantly increased risk of DVT in young people.

Language: Portuguese

Type (Professor's evaluation): Scientific