Cribriform-Morular Variant of Papillary Thyroid Carcinoma Molecular Characterization of a Case With Neuroendocrine Differentiation and Aggressive Behavior

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Jose Cameselle Teijeiro (Author) Other; Lia P Menasce (Author) Other; Beng K Yap (Author) Other; Rovel J Colaco (Author) Other; Patricia Castro (Author) FMUP; Ricardo Celestino (Author) Other; Clara Ruiz Ponte (Author) Other; Paula Soares (Author) FMUP; Manuel Sobrinho Simoes (Author) FMUP

Journal

Title: American Journal of Clinical Pathology

Vol. 131 No. 1

Pages: 134-142

ISSN: 0002-9173

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 41 Citations

Scopus - 61 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-P12

DOI: 10.1309/ajcp7uls0vsisbeb

Abstract (EN): We describe an especially aggressive case of cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) in a 42-year-old man with familial adenomatous polyposis who died with lung and brain metastases 17 months after thyroidectomy. The angioinvasive neoplasm combined a mixture Of trabecular, solid, cribriform, and follicular patterns of growth with CD10+ morules. Follicles were devoid of colloid, and the nuclear features typical of PTC were present in some areas and missing in others. Tumor cells were positive for thyroid transcription factor-1 and, in 40% of the tumoral mass, also were positive for chromogranin and synaptophysin and were negative for thyroglobulin and calcitonin. Strong nuclear staining for beta-catenin was found in all tumor cells, as was positivity for p53 and cyclin D1. In addition to the germline heterozygous APC Ex 2-3 duplication mutation, a somatic homozygous silent p. Thr1493Thr gene variant was found in the neoplastic cells along with RET/PTC rearrangement. This tumor represents the first case of C-MV of PTC showing neuroendocrine differentiation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9