Gastric cancer in a caucasian population: Role of pepsinogen C genetic variants

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Ana L Pinto Correia (Author) Other; Hugo Sousa (Author) Other; Maria Fragoso (Author) Other; Luis Moreira Dias (Author) Other; Carlos Lopes (Author) ICBAS; Rui Medeiros (Author) ICBAS; Mario Dinis Ribeiro (Author) FMUP

Journal

Title: World Journal of Gastroenterology

Vol. 12

Pages: 5033-5036

ISSN: 1007-9327

Publisher: Baishideng Publishing Group

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 15 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-HWV

Abstract (EN): AIM: To study the role of an insertion/deletion polymorphism in the pepsinogen C (PGC) gene, an effective marker for terminal differentiation of the stomach mucosa, in the susceptibility to the development of gastric lesions. METHODS: The study was performed with 99 samples of known gastric lesions and 127 samples without evidence of neoplastic disease. PCR was employed and the 6 polymorphic alleles were amplified: Allele 1 (510 bp), Allele 2 (480 bp), Allele 3/4 (450/460 bp), Allele 5 (400 bp) and Allele 6 (310 bp). RESULTS:'Our results revealed that Allele 6 carriers seemed to have protection against the development of any gastric lesion (OR = 0.34; P < 0.001), non-dysplastic lesions associated with gastric adenocarcinoma such as atrophy or intestinal metaplasia (OR = 0.28; P < 0.001) or invasive GC (OR = 0.39; P = 0.004). CONCLUSION: Our study reveals that the Allele 6 carrier status has a protective role in the development of gastric lesions, probably due to its association with higher expression of PGC. Moreover, the frequency of Allele 6 carriers in the control group is far higher than that obtained in Asian populations, which might represent a genetic gap between Caucasian and Asian populations.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4