-765G > CCOX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Carina Pereira (Author) Other; Hugo Sousa (Author) Other; Paula Ferreira (Author) Other; Maria Fragoso (Author) Other; Luis Moreira Dias (Author) Other; Carlos Lopes (Author) ICBAS; Rui Medeiros (Author) ICBAS; Mario Dinis Ribeiro (Author) FMUP

Journal

Title: World Journal of Gastroenterology

Vol. 12

Pages: 5473-5478

ISSN: 1007-9327

Publisher: Baishideng Publishing Group

Indexing

ISI Web of Knowledge - 49 Citations

Scopus - 55 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-H82

DOI: 10.3748/wjg.v12.i34.5473

Abstract (EN): AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04). CONCLUSION: -765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6