Follicular thyroid carcinoma with an unusual glomeruloid pattern of growth

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Jose Cameselle Teijeiro (Author) Other; Fernando Pardal (Author) Other; Catarina Eloy (Author) FMDUP; Clara Ruiz Ponte (Author) Other; Ricardo Celestino (Author) Other; Patricia Castro (Author) FMUP; Paula Soares (Author) FMUP; Manuel Sobrinho Simoes (Author) FMUP

Journal

Title: Human Pathology

Vol. 39 No. 10

Pages: 1540-1547

ISSN: 0046-8177

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 12 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-VT2

DOI: 10.1016/j.humpath.2008.01.014

Abstract (EN): We describe an uncommon thyroid tumor in a 56-year-old woman. The widely infiltrating, angioinvasive neoplasm, 5 cm in diameter, exhibited a peculiar architectural growth pattern characterized by follicles with round to oval epithelial tufts growing within, often supported by a fibrovascular core mimicking the renal glomerulus. Colloid-empty follicles, tubular or elongated, were lined by pseudostratified tall, columnar cells with clear cytoplasm. Nuclei were round to oval, with evenly distributed, slightly coarse chromatin. Tumor cells were positive for thyroid transcription factor-1, thyroperoxidase, thyroglobulin, cytokeratin 18, Hector Battifora mesothelial cell, and vimentin. Scattered cells positive for S100, Wilms tumor 1 (WT1), and cytokeratins AE1/AE3 were found, with no reaction detected for cytokeratins 34 beta E12, 5/6, 7, 19, or 20. There were PAX8-PPAR gamma rearrangement and N-RAS mutation. No mutations were found for APC or BRAF genes, nor were RET/PTC rearrangements detected. Because of the distinctive histologic features, we propose naming this tumor follicular thyroid carcinoma with an unusual glomeruloid pattern of growth.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8