Canine mammary tumours: A quantitative DNA study using static cytometry

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Fernando Schmitt (Author) FMUP

Journal

Title: Revista Espanola de Patologia

Vol. 44

Pages: 195-201

ISSN: 1699-8855

Publisher: Elsevier

Indexing

Scopus - 3 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-008-10E

DOI: 10.1016/j.patol.2011.05.005

Abstract (EN): Static cytometric analysis of DNA content was performed on formalin-fixed paraffin wax-embedded samples of 56 canine mammary neoplasms (23 benign and 33 malignant) and histology, patient age and immunohistochemical markers were compared between diploid and aneuploid tumours. 10 benign tumours (43.47%) and 16 malignant (48.48%) were aneuploid. No association was found between age and ploidy (P> 0.05). Aneuploidy was not related to age or tumour malignancy (P< 0.05). The expression of the following markers: progesterone receptor, MIB-1, CD-31, p53, c-erbB2, and cyclin D1 did not show significant differences between diploid and aneuploid tumours (P< 0.05). Epithelial and mesenchymal components of benign mixed tumours, complex adenomas and carcinomas in mixed tumours had an identical DNA content in 74.0% of cases suggesting a common cell origin of both components. © 2010 SEAP y SEC.

Language: English

Type (Professor's evaluation): Scientific