Effect of saline load and metoclopramide on the renal dopaminergic system in patients with heart failure and healthy controls

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Margarida Alvelos (Author) FMUP; António Ferreira (Author) FMUP; Bettencourt P (Author) FMUP; Joana Pimenta (Author) FMUP; Azevedo A (Author) FMUP; Paula Serrão (Author) FMUP; Francisco Rocha Gonçalves (Author) FMUP; Patrício Soares da Silva (Author) FMUP

Journal

Title: Journal of Cardiovascular Pharmacology

Vol. 45

Pages: 197-203

ISSN: 0160-2446

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 8 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-000-4GT

DOI: 10.1097/01.fjc.0000152032.46373.e7

Abstract (EN): Dopamine of renal origin has natriuretic/diuretic actions by activating D-1-like receptors of the nephron. Saline load increases renal dopamine production and natriuresis in healthy subjects, and, under these conditions, the activation of D-2-like receptors also produces natriuresis/diuresis. Metoclopramide is a D-2-like receptor antagonist. Patients with heart failure (HF) have an increased renal dopamine-synthesizing efficiency. However, the effect of salt loading was not explored in HE We hypothesized that HF patients respond to salt loading with increased production of renal dopamine and that metoclopramide antagonizes this response. This was a randomized, controlled, crossover study exploring the effect of NaCl and metoclopramide on renal dopaminergic, sympathetic, renin-angiotensin-aldosterone, and arginine-vasopressin (AVP) systems activity on sodium handling in 9 HF patients and 9 controls. NaCl markedly increased renal dopamine production and natriuresis in both groups. Metoclopramide blunted these responses in HF patients but not in controls. NaCl decreased renin and aldosterone plasma levels in controls but not in HF patients. In these patients B-type natriuretic peptide (BNP) levels increased, but AVP was not affected. HF patients respond to salt loading with increased natriuresis. However, the mechanisms for this response are different from those found in healthy subjects. Metoclopramide has antinatriuretic effects only in HF patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7