Cystic tumor of the atrioventricular node of the heart appears to be the heart equivalent of the solid cell nests (ultimobranchial rests) of the thyroid

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Cameselle Teijeiro, J (Author) Other; Abdulkader, I (Author) Other; Soares, P (Author) FMUP; Alfonsin Barreiro, N (Author) Other; Moldes Boullosa, J (Author) Other; Sobrinho Simoes, M (Author) FMUP

Journal

Title: American Journal of Clinical Pathology

Vol. 123 No. 123

Pages: 369-375

ISSN: 0002-9173

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 27 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences

Other information

Authenticus ID: P-000-4B0

DOI: 10.1309/gwt2py0t77pbba1a

Abstract (EN): We studied a series of 10 solid cell nests (SCNs) of the thyroid and a case of cystic tumor of the atrioventricular node (CTAVN) of the heart and reviewed the literature. The CTAVN and SCNs appeared as cystic and/or solid (squamoid) structures mainly composed of polygonal or oval cells (main cells) admixed with occasional clear cells (neuroendocrine and C cells). Main cells were immunoreactive for simple and stratified epithelial-type cytokeratins, epithelial membrane antigen, carcinoembryonic antigen, carbohydrate antigen 19.9, p63, bcl-2, and galectin-3. Neuroendocrine (and C) cells were positive for simple-type cytokeratins, carcinoembryonic antigen, calcitonin, chromogranin, synaptophysin, and thyroid transcription factor-1. Our data support the hypothesis that the CTAVN of the heart and the SCNs of the thyroid are identical structures that represent the same lesional process. The assumption that CTAVN is a ultimobranchial heterotopia fits with the known role of cardiac neural crest cells in cardiovascular development.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7