Age-related changes in the renal dopaminergic system and expression of renal amino acid transporters in WKY and SHR rats

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Vanda Pinto (Author) Other; João Amaral (Author) Other; Elisabete Silva (Author) Other; Sónia Simão (Author) Other; José Miguel Cabral (Author) Other; Joana Afonso (Author) Other; Maria Paula Serrão (Author) Other; Pedro Gomes (Author) Other; Maria João Jorge Pinho (Author) FMUP; Patrício Soares da Silva (Adapter) FMUP

Journal

Title: Mechanisms of Ageing and Development

Vol. 132 No. 6-7

Pages: 298-304

ISSN: 0047-6374

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 10 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-QKJ

DOI: 10.1016/j.mad.2011.06.003

Abstract (EN): This study examined age-related changes in renal dopaminergic activity and expression of amino acid transporters potentially involved in renal tubular uptake of L-DOPA in Wistar Kyoto (WKY) and spontaneously hypertensive rats. Aging (from 13 to 91 weeks) was accompanied by increases in systolic blood pressure (SBP) in both WKY and SHR. The sum of urinary dopamine and DOPAC and the urinary dopamine/L-DOPA ratio were increased in aged SHR but not in aged WKY. The urinary dopamine/renal delivery of L-DOPA ratio was increased in both rat strains with aging. LAT2 abundance was increased in aged WKY and SHR. The expression of 4F2hc was markedly elevated in aged SHR but not in aged WKY. ASCT2 was upregulated in both aged WKY and SHR. Plasma aldosterone levels and urinary noradrenaline levels were increased in aged WKY and SHR though levels of both entities were more elevated in aged SHR. Activation of the renal dopaminergic system is more pronounced in aged SHR than in aged WKY and is associated with an upregulation of renal cortical ASCT2 in WKY and of LAT2/4F2hc and ASCT2 in SHR. This activation may be the consequence of a counter-regulatory mechanism for stimuli leading to sodium reabsorption.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7